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Inwazja problemu nadużywania opioidów oraz rosnąca świadomość zagrożeń związanych z nawet pozornie "łagodnymi" substancjami, takimi jak kodeina, doprowadziły do znaczących zmian w jej statusie prawnym i dostępności w Polsce. Przez długi czas kodeina była powszechnie dostępna bez recepty w wielu preparatach przeciwbólowych i na kas